Xingbo Yang


Contact

Xingbo Yang


Curriculum vitae


xingbo_yang@fas.harvard.edu

Department of Molecular and Cellular Biology and Department of Applied Physics


Harvard University


Northwest Lab Building
52 Oxford Street
Cambridge MA 02138




Xingbo Yang


xingbo_yang@fas.harvard.edu

Department of Molecular and Cellular Biology and Department of Applied Physics


Harvard University


Northwest Lab Building
52 Oxford Street
Cambridge MA 02138



Tissue mechanics and morphogenesis (current)


Mechanical forces are known to play an important role in collective cell migration and morphogenesis. Our understanding of mechanical regulation in these processes are limited by the lack of techniques to measure mechanical forces in vivo. I developed an imaging-based technique, termed mechanical inference, to infer mechanical forces based on cell geometry in epithelial tissues. This method has been validated with laser ablation experiments in drosophila embryo and provides a high throughput approach to map out mechanical forces in vivo. Using this method, we discovered dinstinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis of drosophila embryonic development.

The future objective of this project is to combine mechanical inference with metabolic flux inference to study the interplay of energy dissipation, tissue mechanics and collective cell migration.


Publications


Motility-driven glass and jamming transitions in biological tissues.


Dapeng Bi, Xingbo Yang, M. Cristina Marchetti, M. Lisa Manning


Physical Review X, vol. 6(2), 2016 Mar 20


Correlating cell shape and cellular stress in motile confluent tissues


Xingbo Yang, Dapeng Bi, Michael Czajkowski, Matthias Merkel, M. Lisa Manning, M. Cristina Marchetti


Proceedings of the National Academy of Sciences of the United States of America, vol. 114(48), 2017 Oct 27, pp. 12663-12668


Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis.


Girish R. Kale, Xingbo Yang, Jean Marc Philippe, Madhav Mani, Pierre François Lenne, Thomas Lecuit, Thomas Lecuit


Nature Communications, vol. 9(1), 2018 Oct 26, pp. 5021-5021