Xingbo Yang


Contact

Xingbo Yang


Curriculum vitae


xingbo_yang@fas.harvard.edu

Department of Molecular and Cellular Biology and Department of Applied Physics


Harvard University


Northwest Lab Building
52 Oxford Street
Cambridge MA 02138




Xingbo Yang


xingbo_yang@fas.harvard.edu

Department of Molecular and Cellular Biology and Department of Applied Physics


Harvard University


Northwest Lab Building
52 Oxford Street
Cambridge MA 02138



Division-control in freshwater planarians (past)


Division-control is a fundamental aspect of the life cycle of organisms reproducing through fission. While regulation of division rates have been studied in bacteria and yeast, much less is known about division control in multicellular organisms due to a lack of data. We have, over the course of several years, assembled a unique large-scale data set on the growth and asexual reproduction of two freshwater planarian species, Dugesia japonica and Girardia tigrina, which reproduce by transverse fission and succeeding regeneration of head and tail pieces into new planarians. Analyzing the data with a biophysical model, we discovered diverse division control strategies not only across different species, but across different types of offsprings of the same species. We have also revealed generational memory in the division dynamics. Our findings can serve as a point of departure for future studies on the molecular mechanisms governing planarian asexual reproduction.

Publications


Coordination of size-control, reproduction and generational memory in freshwater planarians


Xingbo Yang, Kelson J. Kaj, David J. Schwab, Eva Maria S. Collins


Physical Biology, vol. 14(3), 2017 Apr 22, pp. 36003-36003